2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W744643
    Butylphthalide-d9 2251692-52-9
    Butylphthalide-d9 (3-n-Butylphthalide-d9) is deuterium labeled Butylphthalide. Butylphthalide (3-n-Butylphthalide) is an active molecule against cerebral ischemia. It was originally isolated from celery species and has been shown to be effective in stroke animal models.
    Butylphthalide-d9
  • HY-W744953
    Carbimazole-d3
    Carbimazole-d3 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
    Carbimazole-d3
  • HY-W745349
    rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride 2517771-79-6
    rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride is the deuterium labeled rel-(1S,2R)-Dihydro bupropion hydrochloride.
    rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride
  • HY-W746625
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester 31930-67-3
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester (all-cis-4,7,10,13,16-DPA methyl ester) is the methyl ester derivative of all-cis-4,7,10,13,16-Docosapentaenoic acid, that can be used as a nutritional supplement to increase all-cis-4,7,10,13,16-Docosapentaenoic acid intake. all-cis-4,7,10,13,16-Docosapentaenoic acid is a long-chain polyunsaturated fatty acid, that plays a role in cardiovascular health, neuroprotection, and inflammation regulation.
    all-cis-4,7,10,13,16-Docosapentaenoic acid methyl ester
  • HY-W747097
    Sacubitrilat-13C4
    Sacubitrilat-13C4 (Desethyl Sacubitril-13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
    Sacubitrilat-13C4
  • HY-W747573
    N-Linolenoylethanolamine 57086-93-8
    N-Linolenoylethanolamine (18:3 NAE) is an endocannabinoid. N-Linolenoylethanolamine is a vanillin receptor (TRPV1) agonist.
    N-Linolenoylethanolamine
  • HY-W748362
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone 1638677-49-2
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone is structurally similar to known synthetic cannabinoids.
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone
  • HY-W751400
    Solasodine hydrochloride 6106-33-8
    Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
    Solasodine hydrochloride
  • HY-W751874
    Acetyl methylene blue 3763-06-2
    Acetyl methylene blue can be used to synthesize mitochondrial development stimulators, which can be used for eye diseases related to insufficient mitochondrial function in nerve cells.
    Acetyl methylene blue
  • HY-W753325
    α-Hydroxy flualprazolam 37115-46-1
    α-Hydroxy flualprazolam is a benzodiazepine.
    α-Hydroxy flualprazolam
  • HY-W753326
    N-Isopropyl hexylone hydrochloride 27912-43-2
    N-Isopropyl hexylone hydrochloride is a cathinone compound
    N-Isopropyl hexylone hydrochloride
  • HY-W753602
    Acetamiprid-N-desmethyl-13C,d3
    Acetamiprid-N-desmethyl-13C,d3 is the 13C and deuterium labeled isotope of Acetamiprid-N-desmethyl(13C,d3)(HY-B0823).Acetamiprid is a nAChR agonist that has been implicated in neuromuscular and reproductive disorders.
    Acetamiprid-N-desmethyl-13C,d3
  • HY-W756790
    MDMB-FUBINACA metabolite M1 2693397-47-4
    MDMB-FUBINACA metabolite M1 is structurally classified as a synthetic cannabinoid.
    MDMB-FUBINACA metabolite M1
  • HY-W767656
    Dropropizine-d4 2514953-45-6
    Dropropizine-d4 ((±)-Dropropizine-d4) is deuterium labeled Dropropizine. Dropropizine ((±)-Dropropizine) belongs to the phenylpiperazine group of organic compounds. Dropropizine is a peripheral antitussive agent that acts by inhibiting cough reflex through its action on the peripheral receptors and their afferent conductors .
    Dropropizine-d4
  • HY-W768607
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer 2365470-99-9
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer is structurally similar to known synthetic cannabinoids.
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer
  • HY-W769938
    FUB-NPB-22 2244864-90-0
    FUB-NPB-22 is an analog of NPB-22 in which the pentyl side chain is replaced by a 4-fluorobenzyl group.
    FUB-NPB-22
  • HY-W774926
    Permethrin-d6 82523-59-9
    Permethrin-d6 (NRDC-143-d6) is deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide and a high selectively inhibitor of the Mitochondrial complex I, found in sediment and water samples. Permethrin shows estrogenic in vivo and anti-estrogenic activity in vitro. Permethrin also acts as a neurotoxin affecting neuron membranes by prolonging Sodium channel activation. Permethrin decreases resistance to bacterial infections in medaka (Oryzias latipes).
    Permethrin-d6
  • HY-W775308
    Cannabicyclolic acid 40524-99-0
    Cannabicyclolic acid is a certified reference material categorized as a photodegradation product of the phytocannabinoid Cannabichromenic acid.
    Cannabicyclolic acid
  • HY-W775325
    7-Hydroxycannabidiol 50725-17-2
    7-Hydroxycannabidiol (7-OH-CBD) is the metabolite of cannabidiol, which could be found in human serum and saliva.
    7-Hydroxycannabidiol
  • HY-W775346
    Delta8-THC acetate 23050-54-6
    Delta8-THC acetate (Delta8-tetrahydrocannabinol) is a psychoactive phytocannabinoid, that binds to cannabinoid receptor 1 (CB1 receptor), and exhibits anti-nausea, appetite-stimulating, and anti-inflammatory activities. Delta8-THC acetate exhibits probably neuroprotective efficacy and can be used in anti-anxiety and antidepressant research.
    Delta8-THC acetate
Cat. No. Product Name / Synonyms Application Reactivity